Suggested links

Mesothelioma Pleurodesis

Mesothelioma pleurodesis is a minor surgery that treats pleural effusions (buildup of fluid in the lung lining) and the symptoms it causes, including chest pain and difficulty breathing. This procedure permanently seals the lung lining so fluid can’t accumulate there. Learn more about the mesothelioma pleurodesis procedure below.

Updated by: Laura Wright on

Our Promise to YouOur Promise to You

What Is Pleurodesis Surgery for Mesothelioma?

Pleurodesis for mesothelioma is a surgical procedure that can help those who suffer from malignant (cancerous) pleural effusions.

Did You Know?

Pleural effusions occur in over 90% of malignant pleural mesothelioma patients, according to a 2022 report from the American Journal of Medicine. They cause shortness of breath, pain, and other symptoms.

It’s possible to drain pleural effusions, but they can reoccur repeatedly in some patients. A mesothelioma pleurodesis can solve this problem.

To perform a mesothelioma pleurodesis, a doctor drains the pleural fluid from the lining of the lungs (pleura). They then irritate the pleural space. There are two layers of the pleura, and a pleurodesis causes them to stick together. This way, the effusions won’t come back.

Top pleural mesothelioma doctors can perform a pleurodesis and other surgeries. Get help finding specialists with our Free Mesothelioma Doctor Match.

Mesothelioma doctor talking with an older couple
Free Mesothelioma Doctor Match

We'll help you connect with a local mesothelioma specialist for personalized treatment.

Find a Doctor Near You

Who Can Benefit From a Pleurodesis for Mesothelioma?

Mesothelioma patients suffering from pleural effusions — particularly ones that won’t go away — are generally good candidates for pleurodesis.

Pleurodesis can ease pleural effusion symptoms like:

  • Breathing difficulties
  • Chest pain
  • Coughing

Doctors can also use a pleurodesis to treat pneumothorax (collapsed lung). By getting a pleurodesis for pneumothorax, the lung lining will be sealed, so air can’t collect inside.

Mesothelioma Pleurodesis vs. Other Treatments

Pleurodesis can be more effective in easing mesothelioma symptoms than another commonly used treatment called a thoracentesis.

While a thoracentesis can be used to drain pleural effusions, it can’t prevent them from coming back.

Further, a pleurodesis may be a good alternative if you don’t wish to get an indwelling pleural catheter. Doctors often recommend catheters to treat recurring pleural effusions, but this requires having a tube inserted in your chest.

“Ask your oncologist his or her thoughts about a talc pleurodesis. This could prevent you from having a pleural catheter.”

— Amy Fair, RN, Mesothelioma Hope Patient Advocate

Finally, it’s important to know that pleurodesis is a palliative treatment. Its main purpose is to improve quality of life. If patients want to live longer, they’ll need to undergo aggressive treatments.

For example, early-stage mesothelioma patients can undergo a major surgery called a pleurectomy with decortication (P/D). The lung lining and all tumors inside are removed, helping to improve the patient’s overall survival. Doctors can perform a pleurodesis during this procedure too.

Types of Mesothelioma Pleurodesis

There are two main types of pleurodesis: chemical and mechanical. Doctors can see which is the best option for a pleural mesothelioma patient when assessing their health care needs.

Chemical Pleurodesis

A chemical pleurodesis treats malignant pleural effusions by injecting what’s known as a sclerosing agent into the pleural cavity. The agent is a chemical that irritates the lung lining.

Chemicals that may be used include:

  • Cisplatin (a chemotherapy drug)
  • Doxycycline
  • Talc slurry (talcum powder and saline mix)

Oncology (cancer) doctors first drain the pleural effusion before administering the sclerosing agent through a chest tube. The pleural layers will then get stuck together.

A chemical pleurodesis is considered a “definitive intervention” for pleural effusions, according to a 2022 American Journal of Medicine report.

Mechanical Pleurodesis

Also known as a dry abrasion, this treatment allows mesothelioma doctors to irritate the pleura themselves rather than using a chemical.

After draining the pleural fluid buildup, the doctor performs surgery to disrupt the pleura, causing inflammation and scarring. This fuses the layers of the pleura together.

Did You Know?

Doctors often use video-assisted thoracoscopic surgery (VATS) to perform a mechanical pleurodesis. This thoracoscopic pleurodesis is done by feeding a tube with a camera at the end into the pleura and then causing irritation.

An article in the medical journal Respiratory Research notes that mechanical pleurodesis is less commonly used than chemical pleurodesis, as it’s a more involved surgery.

Other Options

Besides a chemical or mechanical pleurodesis, doctors can sometimes use other methods to seal the pleura. For example, a 2022 report in Seminars in Interventional Radiology notes that lasers or argon beams can be used as a form of pleurodesis.

If a patient is unable or unwilling to undergo a pleurodesis, doctors may recommend a pleural catheter so the patient will be able to drain the fluid without the need for repeated hospital stays.

Learn about all the pleural mesothelioma treatment options available to you in our Free Mesothelioma Guide.

Mesothelioma Guide Images
Get Your Free 2023 Mesothelioma Guide
  • Symptoms & staging
  • Average prognosis
  • Life-extending treatments

Get Your Free Guide

Steps for Getting a Pleurodesis for Mesothelioma

1. Schedule a Consultation

If a patient is suffering from a pleural effusion, they can reach out to their doctor to get a consultation about a mesothelioma pleurodesis.

During this appointment, the doctor will tell the patient how a pleurodesis works and see if the procedure is right for them.

2. Prepare for Pleurodesis

If doctors believe that a mesothelioma pleurodesis can help a patient, they’ll offer guidelines to prepare for the procedure.

Patients may need to not eat or drink for several hours beforehand. They should also tell doctors about any medications before agreeing to get a pleurodesis, as some (like blood thinners) could affect the procedure.

3. Undergo Pleurodesis

A pleurodesis procedure is a multi-step process.

These steps include:

  1. Apply local anesthetic: The doctor will give the patient a small injection of local anesthetic to ensure the process is as pain-free as possible.
  2. Attach a chest drain: The patient may need to have their pleural effusion drained before undergoing a pleurodesis. In this case, the surgeon will put a needle into the patient’s chest wall and attach it to a drain. It typically takes a few days for all of the excess fluid to be drained out, according to Roswell Park Comprehensive Cancer Center.
  3. Start the surgery: After all the fluid has been drained, doctors can then make a surgical incision, which is needed so they can reach the pleura.
  4. Irritate the pleura: The surgeon will either chemically or mechanically cause irritation within the pleural space so the fluid doesn’t build up again.

Looking to undergo a mesothelioma pleurodesis and other top treatments? We can help. Contact us now to get started.

4. Pleurodesis Recovery

After the pleurodesis, the doctor will seal the incision site so the patient can start to heal.

Pleurodesis Recovery Times

Patients typically need to spend 2 nights in the hospital following a pleurodesis so doctors can make sure they’re recovering properly.

The patient may have pain and feel tired. The oncology care team may give them a prescription or over-the-counter medicine to help with the pain.

Once discharged, the patient can care for themselves by:

  • Avoiding quick movements or lifting heavy objects until they feel better
  • Calling their doctor if possible complications appear (fever, infection, etc.)
  • Resting when they feel tired
  • Taking doctor-prescribed pain medicine

Patients can also schedule a follow-up visit with their doctor as needed.

Pleurodesis Side Effects and Risks

Like any medical procedure, getting a mesothelioma pleurodesis has some side effects and risks.

Pleurodesis complications can include:

  • Breathing difficulties
  • Chest tightness due to inflammation
  • Fever
  • Infection
  • Pain

Many of these symptoms (such as breathlessness and fever) are usually minor and go away within a few days.

Call your doctor if you experience any severe or long-term pleurodesis side effects and are concerned. In an emergency, dial 911.

Find Out if a Mesothelioma Pleurodesis Is Right for You

If you or a loved one has recurrent pleural effusions and are interested in getting a pleurodesis, reach out to Mesothelioma Hope today.

For over 20 years, we have helped mesothelioma patients and their families connect with medical care and access compensation to pay for it.

Our team can help you connect with top mesothelioma specialists, treatments, and financial resources right now. Get started by using our Free Doctor Match to find a mesothelioma specialist near you.

Mesothelioma Pleurodesis FAQs

How long does a pleurodesis last?

A pleurodesis procedure takes about 1.5 hours, but preparing for it and recovering from it may take a bit longer.

How long your pleurodesis will take depends on unique factors in your case. For example, if you need to have fluid drained from your body before the pleurodesis occurs, this can add several more days to the procedure.

What is the survival rate of pleurodesis surgery?

In a report from the Journal of Thoracic Disease, Mount Sinai Health System researchers looked at the survival rates and average life expectancies after pleurodesis among pleural mesothelioma patients.

Those who received a mesothelioma talc pleurodesis lived for 14 months on average, and the 2-year survival rate ranged from 10%-13%.

How serious is pleurodesis?

Mesothelioma pleurodesis is a minimally invasive mesothelioma surgery. This means it’s not usually as intense when compared to other surgeries used to help patients live longer, like a P/D.

However, as with any surgery, there are always risks. Your mesothelioma doctor will discuss any possible risks ahead of time and do everything they can to avoid them.

How long is recovery from pleurodesis?

Most patients will need to stay in the hospital for 2 days to recover from pleurodesis. During this time, they’ll be monitored to make sure they recover properly.

Doctors can provide a better timeline as to when the patient will be fully recovered after they’re dismissed, as it can vary with each case. Generally speaking, it shouldn’t take long for the patient to completely recover from a pleurodesis and feel better.

What are the long-term effects of pleurodesis?

After a mesothelioma pleurodesis, you should find relief as fluid won’t build up around your lungs anymore. Associated symptoms like shortness of breath and chest pain should lessen or disappear as a result.

If these symptoms return after you’ve had a mesothelioma pleurodesis, contact your doctor immediately.

Written by:

Lead Editor

Laura Wright is a journalist and content strategist with more than 15 years of professional experience. She attended college at the University of Florida, graduating magna cum laude with a bachelor’s degree in journalism in 2008. Her writing has been featured in The Gainesville Sun and other regional publications throughout Florida.

Our Promise to You
Our Promise to You
  1. Ali, M., et al. National Library of Medicine: National Center for Biotechnology Information (January 2013). StatPearls. “Pleurodesis.” Retrieved April 6, 2023, from

  2. Cancer Research UK. (2021, July 28). “Treatment for fluid on the lung (pleurodesis).” Retrieved April 6, 2023, from

  3. City of Hope. (2022, September 27). “Pleurodesis.” Retrieved April 28, 2023, from

  4. Cleveland Clinic. (2018, December 18). “Pleural Effusion Causes, Signs & Treatment.” Retrieved April 6, 2023, from–treatment.

  5. Dick, I., et al. National Library of Medicine: PubMed Central (February 2022). Cancer Biomarkers. “Profile of soluble factors in pleural effusions predict prognosis in mesothelioma.” Retrieved April 6, 2023, from

  6. Fysh, E., et al. BMJ Journals: Thorax. (2013). “Pleurodesis outcome in malignant pleural mesothelioma.” Retrieved April 6, 2023, from

  7. Fukui, T., et al, (2021, February 2). “Malignant pleural mesothelioma in a patient with pneumothorax: A cumbersome subtype both clinically and pathologically.” Thoracic cancer, 12(6), 974–977. Retrieved April 28, 2023, from

  8. Gayen, S. (2022 October). “Malignant Pleural Effusion: Presentation, Diagnosis, and Management.” Retrieved April 28, 2023, from

  9. Germonpre, P., et al. BMC: Journal of Cardiothoracic Surgery. (2020). “Recurrence of spontaneous pneumothorax six years after VATS pleurectomy: evidence for formation of neopleura.” Retrieved April 6, 2023, from

  10. Mierzejewski, M, et al. (2019, November 7). “Chemical pleurodesis – a review of mechanisms involved in pleural space obliteration.” Retrieved April 28, 2023, from

  11. (2022, March 9). “Pleurodesis: What to Expect at Home.” Retrieved April 6, 2023, from

  12. National Library of Medicine: PubMed Central (December 2015). Radiology and Oncology. “Release of growth factors after mechanical and chemical pleurodesis for treatment of malignant pleural effusion: a randomized control study.” Retrieved April 6, 2023, from

  13. Penn Medicine (2022, July 31). “About Pleural Effusion.” Retrieved April 6, 2023, from

  14. Roswell Park Comprehensive Cancer Center. (January 2023). “Pleurodesis.” Retrieved April 28, 2023, from

  15. Shojaee, S., et al. National Library of Medicine: PubMed Central (December 2015). Journal of Thoracic Disease. “Thoracoscopy: medical versus surgical—in the management of pleural diseases.” Retrieved April 6, 2023, from

  16. St. Vincent’s Hospital Lung Health. “Pleurodesis.” Retrieved April 6, 2023, from

  17. Taioli, E., et al. National Library of Medicine: PubMed Central (December 2015). Journal of Thoracic Disease. “Review of malignant pleural mesothelioma survival after talc pleurodesis or surgery.” Retrieved April 6, 2023, from

  18. Trivedi, S., et al. (2022, August 31). “Treating Recurrent Pleural Disease: A Review of Indications and Technique for Chemical Pleurodesis for the Interventional Radiologist.” Retrieved April 28, 2023, from

Speak to a Patient Advocate About Your Options

If you or someone you love has been diagnosed with mesothelioma, there is hope. Contact us to learn more about mesothelioma and your treatment options.

  • Latest treatment information
  • Financial assistance for treatment
  • VA benefits help

Submit your information and a Patient Advocate will call you right back!

Complete the Form to Speak to a Patient Advocate