Testicular Mesothelioma

Testicular mesothelioma is an extremely rare form of cancer linked with asbestos exposure. It begins when cancerous tumors form in the protective lining that covers the testicles. Testicular mesothelioma can cause painful symptoms, including excessive swelling. However, it has a slightly better prognosis than mesothelioma that forms in the lining of the lungs, abdominal cavity, or heart.

Fact-Checked and Updated by: Jenna Tozzi, RN

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What Is Testicular Mesothelioma?

Testicular mesothelioma develops in mesothelial tissue, the same type of tissue that lines the lungs, abdomen, and heart. In the testicles, this tissue forms the tunica vaginalis.

When asbestos fibers reach this lining, they can cause damage that builds slowly over time. The body has no way to remove the fibers, so they stay in place and irritate the tissue year after year. Eventually, this long-term irritation can cause healthy cells to change and grow uncontrollably, forming cancer.

Because this process takes time, most people are diagnosed 10 to 50 years after their asbestos exposure, often later in life.

Quick Facts About Testicular Mesothelioma
  • Develops decades after asbestos exposure
  • Makes up less than 1% of all mesothelioma cases
  • Most often affects men over 55 years old
  • Average life expectancy is about 46.7 months
  • Surgery to remove the affected testicle is the most common treatment
  • Care from a mesothelioma doctor is important

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Testicular Mesothelioma Causes

Testicular mesothelioma is caused by exposure to asbestos. For many years, asbestos was widely used in construction, shipbuilding, factories, and industrial products. When asbestos-containing materials were cut, damaged, or worn down, they released tiny fibers into the air.

Most people who were exposed never realized it at the time. They may have breathed in or swallowed asbestos fibers at work, during military service, or while using products that contained asbestos. In many cases, no one warned them about the risks.

Mesothelioma Hope’s legal partners know how to prove asbestos exposure years after it happened. By reviewing your medical records, work history, and any military service, they can identify where your exposure took place and help determine whether you may qualify for compensation.

How Asbestos Exposure Leads to Testicular Mesothelioma

After asbestos fibers enter the body, they can move through the bloodstream or nearby tissues and settle in the tunica vaginalis. Once there, they remain permanently.

Over many years, the fibers irritate the surrounding tissue and cause ongoing inflammation and scarring. This repeated damage can trigger genetic changes in cells, eventually causing them to grow and divide out of control. That uncontrolled growth is what leads to cancer.

Doctors usually have more options when they diagnose testicular mesothelioma early, which can help slow the disease and limit its spread

Testicular Mesothelioma Symptoms

Symptoms of testicular mesothelioma usually affect the scrotum or groin and may start out mild. Because they resemble common conditions, many people do not recognize them as warning signs right away.

Common symptoms include:

  • A lump or mass in the testicle
  • Fluid buildup in the scrotum
  • Persistent pain or discomfort in the groin
  • Swelling or enlargement of one or both testicles

These symptoms develop as the tunica vaginalis thickens and produces extra fluid in response to inflammation.

Doctors sometimes mistake these signs for hernias, infections, or other non-cancerous problems. Because delays can affect treatment options, anyone with ongoing testicular symptoms should see a specialist as soon as possible.

We can help you connect with testicular mesothelioma doctors in your area — try our Free Doctor Match today.

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Testicular Mesothelioma Treatment

Testicular mesothelioma is an aggressive cancer, but treatment can slow its growth, ease symptoms, and help patients live longer. Doctors choose mesothelioma treatments based on how far the cancer has spread and the patient’s overall health. Because this cancer is rare, care from a mesothelioma specialist is important.

Surgery

Surgery is the most common treatment for testicular mesothelioma. Doctors usually remove the affected testicle to get rid of as much cancer as possible and reduce the chance of spread. If cancer has spread to the other testicle or nearby areas, doctors may recommend removing both.

When doctors find the cancer early, surgery can be very effective. Surgery can also help reduce swelling and fluid buildup that cause discomfort.

Chemotherapy

Chemotherapy uses strong drugs to kill cancer cells throughout the body. Doctors may recommend chemotherapy after surgery to target any remaining cancer cells. They may also use it when surgery is not an option.

Because chemotherapy travels through the bloodstream, it can reach cancer cells that have spread beyond the original tumor.

Radiation Therapy

Radiation therapy uses high-energy beams to damage cancer cells and stop them from growing. Doctors may use radiation therapy to help control tumor growth, relieve pain, or treat areas where cancer has spread.

Radiation is often used along with other treatments rather than by itself.

Immunotherapy

Immunotherapy helps the immune system find and attack cancer cells. Doctors most often use immunotherapy when mesothelioma has spread to other parts of the body or has come back after treatment.

Immunotherapy is more common for pleural mesothelioma, but some patients with advanced testicular mesothelioma may be eligible. A mesothelioma specialist can help determine whether immunotherapy is an option based on the cancer stage and overall health.

Testicular Mesothelioma Prognosis and Life Expectancy

Testicular mesothelioma often has a more favorable prognosis, or health outlook, than other types of mesothelioma, especially when doctors diagnose it early. In many cases, the cancer stays limited to the testicle, which makes treatment more effective and can lead to longer survival.

On average, people diagnosed with testicular mesothelioma have a life expectancy of 46.7 months, or just under 4 years. This number reflects the midpoint of survival times, meaning some people live longer, while others live for a shorter period.

Survival rates tend to improve when doctors find the cancer before it spreads. Early treatment, especially surgery to remove the affected testicle, can slow the disease and help prevent it from spreading to other parts of the body. Doctors may also use chemotherapy or other treatments to help control cancer growth.

Research shows that around 49% of people with testicular mesothelioma live 5 years or longer after diagnosis. Your prognosis can vary based on several factors, including how early the cancer is found, whether it has spread, your overall health, and how well the cancer responds to treatment.

Compensation for Testicular Mesothelioma

Compensation is available for testicular mesothelioma because many people were exposed to asbestos without ever being told it was dangerous. Asbestos was used across several industries for much of the 20th century, even after its health risks became known. As a result, innocent people were put at risk without having the chance to protect themselves.

If asbestos exposure led to your diagnosis, you may have options for financial compensation. This support can help with medical bills, travel for treatment, lost income, and long-term care, giving you one less thing to worry about while you focus on your health.

Depending on your situation, compensation may come from:

  • Asbestos trust fund claims
  • Mesothelioma lawsuits
  • VA disability benefits for asbestos exposure during military service
  • Wrongful death claims for families who’ve lost a loved one

Many companies that used asbestos were required to set aside billions of dollars to help people harmed by exposure. Even if your exposure happened decades ago or the company responsible is no longer in business, you may still qualify for compensation.

Get a Free Case Review to learn more about your options. There’s no obligation, and it can give you clarity about whether you qualify for compensation and what steps you can take next.

Find a Testicular Mesothelioma Specialist

Because mesothelioma is such a rare form of cancer, only doctors who have extensive experience in mesothelioma research and treatment can effectively treat affected patients.

If you or someone you love has been diagnosed with testicular mesothelioma, it’s vital to book an appointment with a specialist for a second opinion. General oncologists may not have the expertise required to design an effective treatment plan for this type of cancer.

If you’ve been diagnosed with testicular mesothelioma, contact our Patient Advocates today to find the specialized treatment you need.

Testicular Mesothelioma FAQs

How rare is testicular mesothelioma?

Testicular mesothelioma is incredibly rare. It occurs in less than 1% of all mesotheliomas According to the National Institutes of Health, since the first case was recorded in 1957, there have been less than 1,000 documented cases.

However, it should be noted that diagnosis of testicular mesothelioma can be difficult as the symptoms mimic many other conditions.

What is the survival rate for testicular mesothelioma?

Survival rates for testicular mesothelioma vary, but outcomes are often better than for other types of mesothelioma. A large review published in the medical journal Urology found that about 49% of patients lived at least 5 years after diagnosis, and around 33% lived 10 years or longer. These long-term survival rates are higher than those seen with pleural and peritoneal mesothelioma.

Earlier studies have reported shorter survival times, with many patients living around 2 years on average. Differences in survival depend on several factors, including how early the cancer is found, whether it has spread, the patient’s age and overall health, and the type of treatments used.

Can I have more than one type of mesothelioma?

Though it’s rare, it is possible to have more than one type of mesothelioma. After all, asbestos exposure is the only known cause of mesothelioma, and the different types affect different parts of the body.

The four areas of the body that can be affected are the lungs, abdomen, heart, and testicles.

Jenna TozziWritten by:

Chief Patient Care Advisor

Jenna Tozzi, RN, is the Chief Patient Care Advisor for Mesothelioma Hope. With more than 15 years of experience as an adult and pediatric oncology nurse navigator, Jenna provides exceptional guidance and support to cancer patients and their loved ones. Jenna has been featured in Oncology Nursing News and is a member of the Academy of Oncology Nurse & Patient Navigators & the American Nurses Association.

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References
  1. American Cancer Society. (2024). Mesothelioma – overview. Retrieved from https://www.cancer.org/cancer/types/malignant-mesothelioma.html.
  2. Centers for Disease Control and Prevention. (2023). Asbestos and health. Retrieved from https://www.cdc.gov/niosh/topics/asbestos/default.html.
  3. Cleveland Clinic. (n.d.). Mesothelioma: Types, causes, symptoms & treatment. Cleveland Clinic. Retrieved from https://my.clevelandclinic.org/health/diseases/22432-mesothelioma.
  4. Jiang, Y., et al. (2024). A rare malignant mesothelioma of the tunica vaginalis testis. PMC. U.S. National Library of Medicine. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918515/.
  5. Mayo Clinic. (2024). Mesothelioma: Diagnosis and treatment. Retrieved from https://www.mayoclinic.org/diseases-conditions/mesothelioma/diagnosis-treatment/drc-20375028.
  6. National Cancer Institute. (2025, May 16). Malignant mesothelioma treatment. U.S. Department of Health and Human Services. Retrieved from https://www.cancer.gov/types/mesothelioma/patient/mesothelioma-treatment-pdq.
  7. National Cancer Institute. (2024). Malignant mesothelioma—Patient version. U.S. Department of Health and Human Services. Retrieved from https://www.cancer.gov/types/mesothelioma.
  8. National Health Service. (n.d.). Mesothelioma – treatments. Retrieved from https://www.nhs.uk/conditions/mesothelioma/.
  9. Nazemi, A., et al. (2019). Testicular mesothelioma: An analysis of epidemiology and survival. Urology, 128, 224–230. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S0090429519300640.
  10. Orphanet. (2023). Malignant mesothelioma of the tunica vaginalis testis. Retrieved from https://www.orpha.net/en/disease/detail/685010.
  11. U.S. Department of Veterans Affairs. (2024). Mesothelioma and asbestos exposure. Retrieved from https://www.va.gov/disability/eligibility/hazardous-materials-exposure/asbestos/.
  12. van Zandwijk, N., et al. (2013). Guidelines for the diagnosis and treatment of malignant mesothelioma. Journal of Thoracic Oncology. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886874/.
  13. Vimercati, L., et al. (2019). Asbestos exposure and malignant mesothelioma of the tunica vaginalis testis: A systematic review and the experience of the Apulia (southern Italy) mesothelioma register. Environmental Health, 18, Article 78. Retrieved from https://link.springer.com/article/10.1186/s12940-019-0512-4.
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