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Dr. Jeffrey Clarke

Dr. Jeffrey Clarke

Medical Oncologist

Dr. Jeffrey Melson Clarke is a distinguished medical oncologist who specializes in pleural mesothelioma and lung cancer. He’s earned exceptional patient ratings and reviews for his commitment to understanding each person’s goals for mesothelioma treatment. Learn more about Dr. Clarke and get our help connecting with him today.

or call (866) 608-8933

About Dr. Jeffrey Clarke

Dr. Jeffrey Clarke is an oncologist at Duke Cancer Center in Durham, North Carolina, where he treats patients diagnosed with mesothelioma, lung cancer, and brain and spinal tumors.

He also serves as the Associate Co-Director of Cell-Based Immunotherapy for Duke Cancer Institute’s thoracic cancer disease group.

With a profound understanding of mesothelioma, Dr. Clarke develops personalized treatment plans based on each patient’s specific needs.

“Working closely with my patients — getting to know them and understanding their values and goals — allows me to develop individualized care and treatment.”
– Dr. Jeffrey Clarke, pleural mesothelioma specialist

Find top mesothelioma specialists like Dr. Clarke near you with our Free Doctor Match.

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Dr. Jeffrey Clarke’s Mesothelioma Treatment Approach

Dr. Jeff Clarke takes a multimodal approach to mesothelioma treatment, incorporating two or more treatment methods to most effectively fight this cancer.

He believes in using a combination of therapies tailored to each patient’s specific needs but is particularly experienced with immunotherapy for mesothelioma.

When he’s not treating mesothelioma patients at Duke Cancer Center, Dr. Clarke explores novel therapies and new combinations of existing treatments in clinical trials.

He is known as a compassionate doctor who fosters open communication and understanding with his patients, ensuring they are fully informed and supported throughout treatment.

“The most rewarding part of my work is developing long-term relationships with my patients and their families throughout their cancer journeys.”
– Dr. Jeffrey Clarke, pleural mesothelioma specialist

Dr. Jeffrey Clarke’s Medical Specializations

As a seasoned medical oncologist, Dr. Clarke treats pleural mesothelioma and a wide range of other diseases and cancers using advanced treatment methods.

His medical specialties include:

Dr. Clarke also specializes in the following treatments:

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Dr. Jeffrey Clarke’s Medical Background

Dr. Clarke earned his medical degree from the Indiana University School of Medicine in 2008.

He completed a residency in internal medicine at Duke University Medical Center in 2011, followed by a fellowship in medical oncology at the same institution in 2015.

In addition to seeing patients at Duke Cancer Center, Dr. Clarke holds positions as an associate professor of medicine in medical oncology at the Duke University School of Medicine and a member of the Duke Cancer Institute, reflecting his commitment to professional education and cancer research.

With over a decade of experience in oncology, Dr. Clarke has dedicated his career to advancing cancer treatment. He’s also played a pivotal role in clinical trials for mesothelioma and lung cancer.

Highlights of Dr. Jeffrey Clarke’s Professional Career

Throughout his career, Dr. Clarke has garnered recognition for his exceptional work in the field of oncology.

Appointments and Accolades

Dr. Clarke’s professional and academic contributions have led him to be recognized by both the Duke University Health System and the Duke University School of Medicine.

These recognitions include:

  • Appointment as Associate Professor of Medicine in Medical Oncology
  • Membership in the Duke Cancer Institute
  • Recognition for Excellence in Patient Care

Professional Affiliations

Dr. Clarke also holds several licenses and affiliations related to internal medicine and medical oncology.

These affiliations include:

  • Board certification in medical oncology by the American Board of Internal Medicine
  • Board certification in internal medicine by the American Board of Internal Medicine
  • North Carolina State Medical License

Dr. Jeffrey Clarke’s Published Works

Dr. Clarke’s dedication to advancing treatment is evident in his extensive cancer research and publications.

Some of his most recent published works include:

  • “Long-term Intracranial Outcomes with Combination Dual Immune-Checkpoint Blockade and SRS in Patients with Melanoma and NSCLC Brain Metastases.” Published in the International Journal of Radiation Oncology, Biology, Physics, December 2023.
  • “T-cell responses to individualized neoantigen therapy (INT) mRNA-4157 (V940) as monotherapy or in combination with pembrolizumab.” Published in The Journal for ImmunoTherapy of Cancer, October 2023.
  • “Results from a first-in-human phase 1B study of a complement factor H inhibitor (GT103) in patients with non-small cell lung cancer (NSCLC).” Published in the Journal of Clinical Oncology, June 2023.
  • “Socioeconomic disparities in immunotherapy use among advanced-stage non-small cell lung cancer patients: analysis of the National Cancer Database.” Published in Scientific Reports, May 2023.

By continuously pushing the boundaries of cancer research, Dr. Clarke is helping advance the field of oncology and providing hope to those affected by mesothelioma.

Use our Free Doctor Match now to connect with leading mesothelioma experts like Dr. Clarke in your area.

Mesothelioma doctor talking with an older couple
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We'll help you connect with a local mesothelioma specialist for personalized treatment.

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Dr. Jeffrey Clarke’s Work in Cancer Treatment and Research

Dr. Clarke’s contributions to clinical trials, particularly in investigating novel treatments for lung cancer and mesothelioma, have shown improvements in patient survival rates.

His research efforts have also contributed to the development of personalized treatment strategies such as immunotherapy to target cancer cells more effectively.

Dr. Clarke is currently working with other mesothelioma doctors on a clinical trial testing the combination of surgery and immunotherapy in patients with sarcomatoid mesothelioma, the most aggressive cell type of this cancer.

Get Connected to Dr. Jeffrey Clarke

If you or a loved one are seeking specialized care for mesothelioma in the Raleigh-Durham area, Dr. Clarke is currently accepting new patients at Duke Cancer Center.

His expertise in mesothelioma treatment, coupled with his patient-centered approach, ensures you’ll receive the personalized care and attention you deserve.

“Duke is a remarkable place where world-class people come together with the common goal of trying to provide the very best exceptional care to patients and their families, and doing so in a comprehensive way.”
– Dr. Jeffrey Clarke, pleural mesothelioma specialist

Mesothelioma Hope can help you connect with Dr. Clarke and other top mesothelioma specialists right now. Call (866) 608-8933 or use our Free Doctor Match to get started.

Mesothelioma Hope has no affiliation with and is not endorsed or sponsored by Dr. Jeffrey Clarke. Any contact information listed is for informational purposes only. You have the right to contact Dr. Jeffrey Clarke directly.

Jenna TozziWritten by:

Director of Patient Advocacy

Jenna Tozzi, RN, is the Director of Patient Advocacy at Mesothelioma Hope. With more than 15 years of experience as an adult and pediatric oncology nurse navigator, Jenna provides exceptional guidance and support to mesothelioma patients and their loved ones. Jenna has been featured in Oncology Nursing News and is a member of the Academy of Oncology Nurse & Patient Navigators & the American Nurses Association.

Our Promise to You
Our Promise to You
  1. Baylor College of Medicine. (2023, November 8). BCM, Duke University to study surgery treatment for mesothelioma. Retrieved March 18, 2024, from
  2. Duke Cancer Institute. (n.d.). A082101 Sarcomatoid Mesothelioma Stage 1-3. Retrieved March 18, 2024, from
  3. Duke Cancer Institute. (2024, January 17). Thoracic Cancer. Retrieved March 18, 2024, from
  4. Duke Health Provider Files. (2022, April 16). Jeffrey Melson Clarke, MD. Retrieved March 18, 2024, from
  5. Duke University Health System. (n.d.). Jeffrey Melson Clarke, MD. Retrieved March 18, 2024, from
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