Dr. Edward Levine

Dr. Edward Levine is a surgical oncologist with over two decades of experience treating mesothelioma. He currently leads the Hyperthermic Intraperitoneal Chemotherapy (HIPEC) team at Wake Forest Medical Center, where he has improved the length and quality of life for hundreds of mesothelioma patients.

Mesothelioma Hope has no affiliation with and is not endorsed or sponsored by Dr. Edward Levine. Any contact information listed is for informational purposes only. You have the right to contact Dr. Edward Levine directly.

Quality of life is important to Dr. Levine, which he demonstrated by completing research trials that investigated his patients’ quality of life after completing HIPEC. He has also studied survival outcomes, tumor genomics and the types of chemotherapy drugs used in the HIPEC procedure.

Dr. Levine is nationally recognized for his surgical expertise, clinical trials, and treatment of patients with peritoneal mesothelioma.

“The HIPEC procedure represents a significant advance in the approach of patients who have had tumors which have spread inside the peritoneal cavity and other places. This gives us real options with the hope of long-term, disease-free survival with good quality of life.” -Dr. Edward Levine

Dr. Levine’s Location

Mesothelioma patients interested in working with Dr. Levine to receive HIPEC and other advanced treatments can contact him through:

Wake Forest Baptist Medical Center

Medical Center Boulevard

Winston-Salem, NC  27157


Dr. Levine’s Career Highlights

Dr. Levine has had an extensive career dedicated to advancing chemotherapy technologies for mesothelioma patients. His career highlights include:

  • Leads the heated chemotherapy program at Wake Forest Medical Center
  • Helped lead one of the world’s largest quality of life study for HIPEC patients
  • Has researched new HIPEC chemotherapy agents to help expand treatment options

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Dr. Levine’s Background

Dr. Edward Levine began his post-secondary education at Northern Illinois University, where he graduated with a Bachelor of Science degree. From there, he completed his MD at Rosalind Franklin University of Medicine and Science, followed by a general surgical residency at Michael Reese Hospital in Chicago. Two years later, he completed his residency in oncology at the University of Illinois Hospital.

Dr. Levine then worked at Louisiana State University, before joining the Comprehensive Cancer Center at Wake Forest Medical Center in North Carolina.

During his time at Wake Forest Medical Center, Dr. Levine has made significant contributions towards the understanding and treatment of peritoneal mesothelioma. His research has covered many topics and resulted in over 150 published works, many of which focus on mesothelioma and HIPEC.

Medical Specializations

Dr. Levine is a surgical oncologist, who specializes in peritoneal diseases. He runs the heated chemotherapy team at Wake Forest Medical Center, which has performed the procedure on more than 1000 patients to date. Heated chemotherapy, or Hyperthermic Intraperitoneal Chemotherapy (HIPEC), is widely considered the most successful method of treating peritoneal mesothelioma.

“Wake Forest Baptist Medical Center enjoys one of the largest experiences in the world with cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy. We’ve performed this complex procedure in over a thousand patients.” -Dr. Edward Levine

Dr. Levine has also completed research to better understand and improve the HIPEC procedure itself. One of his studies reviewed the long-term outcome for patients who received the HIPEC treatment, while another experimented with new chemotherapy drugs that can be used in the procedure.

Although Dr. Levine is widely recognized for his work with mesothelioma, he is also an expert in rare appendix and colon cancers.

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Dr. Levine’s Career Accomplishments

Dr. Levine stands out in the medical community for his extensive knowledge of mesothelioma, and ample experience with treating the lengthy disease. In addition to leading the heated chemotherapy team at Wake Forest, Dr. Levine has also completed numerous research trials on mesothelioma and other peritoneal conditions. Some of these trials have focused on patient quality of life, while others attempt to find methods of increasing survival outcomes.

“To patients, I would say that even though your type of tumor is rare with only about 3,000 new cases per year, don’t feel alone.  There is active research taking place for this type of cancer.” -Dr. Edward Levine

Awards & Honours

  • Best Doctors In America
  • Top Doctor for Cancer
  • CMS Meaningful Use Stage 1 Certification
  • EpicCare Inpatient – Core EMR
  • ACS Fellow

Dr. Levine’s Current Work

Dr. Edward Levine is the currently the Director-At-Large for the Comprehensive Cancer Center at Wake Forest Medical Center in North Carolina. He has developed a particular interest in treating mesothelioma and other thoracic cancers and has dedicated his career to understanding these diseases and improving patient survival.

Dr. Levine’s work has received numerous grants for his research into the genomics of tumors and is supported by organizations like the National Surgical Breast and Bowel Project and the American College of Surgeons Oncology Group.

Dr. Levine is also an active member of many professional organizations, including:

  • Connective Tissue Oncology Society
  • Association of Academic Surgery
  • Southern Surgical Association
  • American College of Surgeons

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Notable Work by Dr. Levine

In this study, Dr. Levine researched the survival rates for individuals with diffuse malignant peritoneal mesothelioma. Currently, diffuse peritoneal mesothelioma survival rates are calculated using a system based on malignant pleural mesothelioma, even though the diseases behave differently and require different treatments.

His publication, “A histomorphologic grading system…” created a two-tier system using the number of epithelioid cells present in peritoneal mesothelioma cases, and analyzed against the patients’ survival. The study categorized the tumors into low-grade or high-grade based on the microbiology of the cells and then plotted their survival rate.

The study ultimately concluded that patients with low-grade diffuse peritoneal mesothelioma lived for several years longer after treatment than those with high-grade diffuse mesothelioma. Dr. Levine’s work in this area is important because previously, peritoneal mesothelioma didn’t have an effective staging system compared to pleural mesothelioma.

Dr. Levine’s Healing Philosophy

Dr. Levine believes that the best healing comes when individuals are in the best possible physical, mental, and spiritual shape.

“Take time to prepare yourself well before the surgery. Come to this treatment in the best possible shape.  By that I mean not just physiologically and nutritionally, but also your mental state and spiritual state—all of these are important. The better the shape you are in, the better the outcome.” -Dr. Edward Levine

Dr. Levine also values quality of life and recognizes the role it plays in the healing process. He recommends that his patients do whatever they need to improve their quality of life before, during and after treatment. He recognizes that comfort and familiarity are a critical part of this process.

“Around the time of your surgery, prepare for things that will improve your quality of life in those weeks. Get to know your surgeon, talk about what to expect, get to know the hospital you will be spending time in. Both the patients and caregivers need to know their surroundings and their surgeon in order to keep stress in check and to take care of themselves as well as possible while going through surgery.” -Dr. Edward Levine

Dr. Levine has been an integral part of the leadership team at Wake Forest Baptist Medical Center and helps led and follow the facility’s core mission and values. The facility strives to improve the health of Americans through effective leadership and biomedical research.

Wake Forest Medical Center has many core values: excellence, compassion, service, integrity, diversity, collegiality, and innovation. Together, these values make up the healing philosophy of the facility. Wake Forest also promises to keep patients safe, respect and care for them, and involve patients and their family.

Mesothelioma Hope was founded by a team of passionate health advocates to educate people about this aggressive form of cancer. Mesothelioma affects thousands of people each year. Our team works tirelessly to give hope to those impacted by mesothelioma. Learn more about operating principles and our Editorial Guidelines.

4 References
  1. Wake Forest Baptist Health. “Edward A. Levine, M.D.” Retrieved from http://www.wakehealth.edu/Faculty/Levine-Edward-A.htm. Accessed on November 12th, 2017.

  2. YouTube. “A National Leader in Hyperthermic Intraperitoneal Chemotherapy.” Retrieved from https://www.youtube.com/watch?v=GtEr2dlXk54. Accessed on November 12th, 2017.

  3. PMP Pals Network. “Focus on Physicians: Dr. Edward Levine from Wake Forest Baptist Medical Center” Retrieved from https://pmppals.net/focus-on-physicians-dr-edward-levine-from-wake-forest-baptist-medical-center/. Accessed on November 12th, 2017.

  4. US National Library of Medicine National Insitiutes of Health, “A Histomorphologic Grading System That Predicts Overall Survival in Diffuse Malignant Peritoneal Mesothelioma With Epithelioid Subtype”, Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029445/. Accessed on November 15, 2017.

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