Suggested links

Peritonectomy for Mesothelioma

Peritonectomy is a surgical procedure to remove the lining of the abdominal cavity. It’s often performed as part of cytoreductive surgery — in which cancer is removed from the abdomen — to help pleural mesothelioma patients live longer. Our team can help you access top treatments like a peritonectomy for mesothelioma if you qualify. Learn more below.

Fact-Checked and Updated by: Jenna Tozzi, RN

Last updated:

What Is a Peritonectomy for Mesothelioma?

A peritonectomy is a commonly used treatment for malignant peritoneal mesothelioma.

Peritonectomy Definition

A peritonectomy is a surgical procedure in which doctors remove the parietal peritoneum (the outer lining of the abdomen).

A peritonectomy for mesothelioma might be performed as part of a more extensive treatment known as cytoreductive surgery or debulking. This treatment was developed by peritoneal mesothelioma specialist Dr. Paul Sugarbaker in 1995 and has become the gold standard in treating this cancer.

Peritonectomy for Mesothelioma Video Thumbnail

A peritonectomy is a commonly used surgery for peritoneal mesothelioma. It allows doctors to remove the abdomen lining and any cancer tumors found inside. This surgery may be able to help you or a loved one live longer after a peritoneal mesothelioma diagnosis. View Transcript.

Duration: 1 min 01 sec

If you or a loved one has been diagnosed with peritoneal mesothelioma you may have heard of a surgical procedure called peritonectomy. This procedure involves removing the lining of the abdominal cavity which can help mesothelioma patients live longer. A peritonectomy is often performed as part of cytoreductive surgery which is a comprehensive cancer treatment aimed at removing as many visible abdominal tumors as possible. This type of surgery has been shown to greatly improve survival time for peritoneal mesothelioma patients. A peritonectomy is a complex procedure performed by a team of highly trained surgeons and can take several hours to complete. Our team can help you access top treatments like a peritonectomy if you qualify. We work with leading Cancer Centers across the country to provide patients with the best possible care. Mesothelioma Hope is here to support your family at every step of your cancer journey. To learn more about peritonectomy and other treatment options for mesothelioma, contact us today.

Cytoreductive surgery removes the peritoneum and cancer neoplasms (growths or tumors) through a peritonectomy. Other surgical techniques and heated chemotherapy will also be used during cytoreductive surgery to help patients.

If you’re looking to get a peritonectomy surgery or other top mesothelioma treatments, we can help. Connect with skilled specialists now using our Free Mesothelioma Doctor Match.

Mesothelioma doctor talking with an older couple
Free Mesothelioma Doctor Match

We'll help you connect with a local mesothelioma specialist for personalized treatment.

Find a Doctor Near You

What to Expect During a Peritonectomy for Mesothelioma

1. Surgical Consultation

The first step is a consultation with a surgical oncology (cancer) team. Consultations let patients meet the surgical team virtually or in-person to learn about cytoreductive surgery and the peritonectomy procedure.

During the consultation, oncologists will review the patient’s medical records and see if cytoreductive surgery will be a good fit for their case. They also will provide guidance about how to prepare for the surgery and what to expect afterward.

2. Cytoreductive Procedure

Peritonectomy for mesothelioma and cytoreductive surgery are performed under general anesthesia. During the procedure, the team will remove the peritoneum and as much cancerous tissue as possible.

Did You Know?

Dr. Sugarbaker’s peritonectomy procedure involves performing the surgery up to six times on different spots within the abdomen to get rid of all the cancerous tumors.

The doctors may also remove cancerous portions of nearby organs like the liver if the cancer has spread (metastasized). Instead of a peritonectomy, a different surgical technique called resection is used in these cases.

3. Heated Chemotherapy

Once the peritonectomies and overall cytoreductive surgery have been completed, doctors will treat the patient with hyperthermic intraperitoneal chemotherapy (HIPEC) to destroy microscopic cancer cells.

This is performed by administering heated chemotherapy drugs right into the surgery site. Doxorubicin, mitomycin C, and cisplatin are the most commonly used HIPEC medications, as noted in a report published in the journal BJS Open.

In total, cytoreduction with HIPEC can take up to 10 hours, according to the University of Maryland Medical System.

4. Peritonectomy Recovery

After getting cytoreductive surgery — including peritonectomy and HIPEC — the patient can expect a hospital stay ranging from 8-22 days while they recover, as noted by Moffitt Cancer Center.

Patients will also likely receive food and fluids through an IV at first before returning to a solid diet.

Once discharged, the patient should rest at home for a few more weeks. Moffitt Cancer Center notes that it takes 3 months in total to recover from cytoreduction with HIPEC. The patient should attend follow-up appointments with their oncologists after discharge.

Not sure if you’re a candidate for a mesothelioma peritonectomy? Contact us now.

Peritonectomy Side Effects and Risks

Patients who undergo a peritonectomy for mesothelioma could suffer from postoperative side effects or complications.

Peritonectomy complications include:

  • Excessive bleeding
  • Fever
  • Ileus (intestinal muscles won’t contract)
  • Infections
  • Leakage from surgery site
  • Nausea and vomiting
  • Pneumonia
  • Pulmonary embolism (blockage in pulmonary arteries)
  • Renal (kidney) damage
  • Shortness of breath
  • Urinary tract infections

Severe complications like fistulas (abnormal connections between organs), sepsis, and morbidity (death) can also occur in some patients who receive mesothelioma peritonectomies as part of cytoreductive surgery.

If the patient experiences any of the symptoms above after discharge, they should call their health care team as soon as possible to get help.

Who Can Undergo a Peritonectomy for Mesothelioma?

Doctors can see if you can safely undergo cytoreduction with HIPEC once your peritoneal mesothelioma diagnosis is confirmed.

Ideally, patients should be in good overall health if they want to receive this surgery. This is because cytoreduction with HIPEC is very aggressive and taxing on the body.

Doctors will also need to see how far the cancer has spread through the patient’s body before starting any treatment plan.

Did You Know?

Some peritoneal mesothelioma patients have cancer that’s unresectable, meaning a peritonectomy and other surgeries won’t remove it fully. Other patients may not want to undergo major surgery. In these cases, doctors will recommend using chemotherapy alone to shrink cancer tumors.

How Peritonectomy for Mesothelioma Affects Prognosis

As part of cytoreduction with HIPEC, a peritonectomy for mesothelioma can greatly improve a mesothelioma patient’s prognosis (health outlook). It’s possible for many patients to achieve long-term survival following this treatment.

A 2022 report published by the Journal of Clinical Medicine looked at past studies in which patients were treated with cytoreductive surgery and HIPEC.

The study authors found:

  • The life expectancy of peritoneal mesothelioma patients ranged from 3-5 years
  • The 5-year survival rates (number of patients still alive after 5 years) were between 36% and 53%

Some peritoneal mesothelioma patients have lived for 15 years or more following this treatment plan.

Without undergoing treatments like a peritonectomy for mesothelioma, patients typically live for 6 months to 1 year, as noted in a 2020 report published by Translational Lung Cancer Research.

Get our Free Mesothelioma Guide to learn more about treatments that can help improve your prognosis and quality of life.

Mesothelioma Guide Images
Get Your Free 2024 Mesothelioma Guide
  • Symptoms & staging
  • Average prognosis
  • Life-extending treatments

Get Your Free Guide

Find Out If Mesothelioma Peritonectomy Is Right for You

If you or a loved one has peritoneal mesothelioma and are interested in undergoing a peritonectomy, reach out to Mesothelioma Hope now. For over 20 years, our team has helped mesothelioma patients and their families access life-changing treatment.

We can connect you with:

  • Doctors and cancer centers that treat mesothelioma
  • Financial resources to help cover medical expenses
  • Resources to help cope with cancers caused by asbestos exposure
  • Skilled mesothelioma nurses

Get started on your path to healing right now using our Free Doctor Match.

Peritonectomy for Mesothelioma FAQs

What is the survival rate of peritonectomy?

When performed as part of cytoreductive surgery, peritonectomy for peritoneal mesothelioma patients has a high survival rate.

A 2022 study published in the Journal of Clinical Medicine found that up to 53% of patients were still alive 5 years after they received cytoreduction with HIPEC.

A peritonectomy for mesothelioma is a crucial part of what makes cytoreductive surgery a success, as it allows doctors to remove cancer tumors from the abdominal lining.

What is the life expectancy of someone with peritoneal mesothelioma?

The average life expectancy of peritoneal mesothelioma patients ranges from patients 3-5 years, provided that they get a peritonectomy, cytoreductive surgery, and HIPEC.

What is the best treatment for peritoneal mesothelioma?

If the patient is looking to live longer, aggressive treatments like cytoreduction with HIPEC and a peritonectomy for mesothelioma will be the most effective. By getting these treatments, patients have a better chance at becoming long-term survivors.

If the patient can’t receive life-extending treatment options due to peritoneal metastasis (cancer spread past the abdominal lining), they can undergo palliative care.

Palliative treatments can improve quality of life and ease symptoms like ascites (fluid buildup in the abdomen). Palliative treatments include fluid drains, pain-relieving medications, and systemic chemotherapy.

Finally, peritoneal mesothelioma patients may look into receiving clinical trials (in which new treatments are tested) if standard therapies don’t work for them.

What is the surgery for peritoneal mesothelioma?

The most effective surgery for peritoneal mesothelioma is called cytoreduction with HIPEC.

Doctors first perform peritonectomies and other surgeries to remove the cancer from the abdominal lining and parts of the gastrointestinal tract. Then they send warm chemotherapy drugs into the abdomen to destroy leftover cancer cells.

This treatment can help some peritoneal mesothelioma patients live for years or even decades. It can also help patients with other peritoneal surface malignancies (cancers) like ovarian cancer.

Jenna TozziWritten by:

Director of Patient Advocacy

Jenna Tozzi, RN, is the Director of Patient Advocacy at Mesothelioma Hope. With more than 15 years of experience as an adult and pediatric oncology nurse navigator, Jenna provides exceptional guidance and support to mesothelioma patients and their loved ones. Jenna has been featured in Oncology Nursing News and is a member of the Academy of Oncology Nurse & Patient Navigators & the American Nurses Association.

Our Promise to You
Our Promise to You
  1. Bijelic, L., et al. (2012, August 8). Gastroenterology Research and Practice. “Adjuvant Bidirectional Chemotherapy with Intraperitoneal Pemetrexed Combined with Intravenous Cisplatin for Diffuse Malignant Peritoneal Mesothelioma.” Retrieved February 20, 2024, from
  2. Brandl, A., et al. (2020, January 20). “Clinical and surgical outcomes of patients with peritoneal mesothelioma discussed at a monthly national multidisciplinary team video-conference meeting.” Retrieved February 20, 2024, from
  3. Cancer Council Australia. (February 2023). “Understanding Mesothelioma.” Retrieved February 20, 2024, from
  4. Cancer Research UK. (2023, January 11). “Surgery for peritoneal mesothelioma.” Retrieved February 20, 2024, from
  5. Greenbaum, A., & Alexander, H. R. (2020, February 9). Translational Lung Cancer Research. “Peritoneal mesothelioma.” Retrieved February 20, 2024, from
  6. Li, C., et al. (2022, March 29). Journal of Clinical Medicine. “Treatment of Patients with Malignant Peritoneal Mesothelioma.” Retrieved February 20, 2024, from
  7. McMullen, J. R. W., Selleck, M., Wall, N. R., & Senthil, M. (2017). Peritoneal carcinomatosis: limits of diagnosis and the case for liquid biopsy. Oncotarget, 8(26), 43481–43490. Retrieved February 20, 2024, from
  8. Mehta, S. S., Bhatt, A., & Glehen, O. (2016). Cytoreductive Surgery and Peritonectomy Procedures. Indian journal of surgical oncology, 7(2), 139–151. Retrieved February 20, 2024, from
  9. Mehta, S. S., Gelli, M., Agarwal, D., & Goéré, D. (2016). Complications of Cytoreductive Surgery and HIPEC in the Treatment of Peritoneal Metastases. Indian journal of surgical oncology, 7(2), 225–229. Retrieved February 20, 2024, from
  10. Moffitt Cancer Center. (n.d.). “How Long Does It Take to Recover From a HIPEC Surgery?” Retrieved February 20, 2024, from
  11. Saadeh, R., et al. (2022, February 15). European Journal of Gynaecological Oncology. “Total parietal peritonectomy for 61 patients: A retrospective study.” Retrieved February 20, 2024, from
  12. St. George Peritonectomy & Liver Cancer Unit. (n.d.). “Post-Surgery.” Retrieved February 20, 2024, from
  13. Sugarbaker, P. (2013, April 27). Translational Gastrointestinal Cancer. “Cytoreductive surgery using peritonectomy and visceral resections for peritoneal surface malignancy.” Retrieved February 20, 2024, from
  14. Sugarbaker, P. (2021, September 6). International Journal of Surgery Case Reports. “Peritonectomy of the colonic mesentery. Case report of a new surgical technology.” Retrieved February 20, 2024, from
  15. Sugarbaker, P. (October 2018). Translational Lung Cancer Research. “Update on the management of malignant peritoneal mesothelioma.” Retrieved February 20, 2024, from
  16. University of Maryland Medical System. (n.d.). “Cytoreductive Surgery and HIPEC – FAQs.” Retrieved February 20, 2024, from
  17. Vidal, C., et. al. (August 2022). Cureus. “Malignant Peritoneal Mesothelioma: A Challenging Case for Palliative Care.” Retrieved February 20, 2024, from
  18. Zahid, A., et al. (March 2021). Oxford Academic: BJS Open. “Outcomes of multicystic peritoneal mesothelioma treatment with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.” Retrieved February 20, 2024, from
Free 30-Minute ConversationWith Jenna Tozzi, RN
Fill Out Your Contact Information
How We Can Help

Mesothelioma Hope is passionate about helping patients and families affected by this aggressive cancer. A mesothelioma diagnosis can be scary and isolating, but we’re here for you at every step. Hope is only a phone call away.

(866) 608-8933
Medical Guidance
  • Get a second opinion
  • Find a doctor or cancer center
  • Access clinical trials
  • Improve your quality of life
Financial Assistance
  • Access $30 billion in trust funds
  • File a mesothelioma claim
  • Increase your VA benefits
  • Apply for travel grants
Supportive Care
  • Find a support group or peer mentor
  • Get help with daily tasks
  • Explore respite care options
  • Navigate life post-treatment