City of Hope Orange County Cancer Center for Mesothelioma

City of Hope Orange County Lennar Foundation Cancer Center

City of Hope Orange County Lennar Foundation Cancer Center offers advanced mesothelioma care for patients in Irvine, Los Angeles, and across Southern California. The center is supported by leading research, collaborative treatment teams, and access to innovative clinical trials. Get connected with City of Hope Orange County mesothelioma specialists today.

About City of Hope Orange County Lennar Foundation Cancer Center

City of Hope Orange County is a National Cancer Institute (NCI)-designated mesothelioma treatment center in Irvine, California. Mesothelioma patients receive advanced medical care and research-driven therapies that can help them potentially live longer and more comfortably with this cancer.

City of Hope Irvine offers:

Access to specialized surgeries
Advanced imaging, such as CT and PET scans
Expert lab review of biopsy samples to confirm mesothelioma
Genetic and tumor testing to guide treatment decisions
On-site infusion services for chemotherapy

This location also works directly with City of Hope Comprehensive Cancer Center, one of the nation’s leading cancer hospitals. That connection gives Orange County patients access to the same expertise, research programs, and experienced mesothelioma specialists found at the Duarte campus.

Mesothelioma Doctors at City of Hope Orange County

City of Hope Orange County Lennar Foundation Cancer Center gives patients access to doctors who specialize in mesothelioma and other complex cancers. These physicians work together to create personalized treatment plans based on each patient’s type of mesothelioma, cancer stage, and overall health.

City of Hope Orange County mesothelioma doctors include:

Dr. Jyoti Malhotra: Medical oncologist
Dr. Mustafa Raoof: Surgical oncologist
Dr. Yanghee Woo:Surgical oncologist

These specialists collaborate across thoracic surgery, surgical oncology, medical oncology, and radiation oncology to deliver comprehensive mesothelioma care at City of Hope Orange County Hospital.

If you or a family member is seeking mesothelioma treatment in California, our team can help connect you with specialists at City of Hope Orange County and other top cancer centers. Get started today with our Free Doctor Match service.

Mesothelioma Treatment Options at City of Hope Orange County

Each mesothelioma diagnosis is unique. At City of Hope Orange County Lennar Foundation Cancer Center, treatment plans are based on the patient’s mesothelioma stage, cell type, and other factors.

In many cases, treatment involves a combination of therapies, such as surgery, chemotherapy, immunotherapy, and sometimes radiation, to give patients the best possible outcomes.

Mesothelioma Surgery

Surgery can be one of the most important treatment options for mesothelioma when the cancer is caught at an earlier stage and hasn’t spread extensively.

For pleural mesothelioma, City of Hope surgeons may consider two operations:

Pleurectomy with decortication to remove the cancerous lung lining and visible tumor while keeping the lung in place
Extrapleural pneumonectomy to remove the affected lung along with the surrounding lining and nearby tissue

Patients with peritoneal mesothelioma (which affects the abdominal lining) may benefit from cytoreductive surgery. This procedure removes all visible tumors from the abdominal cavity and is followed up with heated chemotherapy (HIPEC) to kill remaining cancer cells.

Chemotherapy

Chemotherapy is a standard part of mesothelioma treatment at City of Hope Orange County. It uses medications that target rapidly dividing cancer cells.

Mesothelioma chemotherapy may be used:

Before surgery to shrink tumors
After surgery to kill leftover cancer cells
As primary treatment when surgery isn’t an option

Treatments are delivered in the infusion center at City of Hope Hospital in Orange County. Nurses monitor mesothelioma patients closely and provide medications to reduce nausea, fatigue, and other side effects.

Immunotherapy

Immunotherapy helps your body’s natural defenses find and fight mesothelioma. By helping immune cells better recognize cancer cells, mesothelioma immunotherapy may slow the disease and help some patients live longer.

City of Hope Orange County offers FDA-approved immunotherapy medications for mesothelioma like Opdivo® and Yervoy® and participates in ongoing research to expand treatment options. Eligible patients may have access to clinical trials studying new immunotherapy drugs and combinations of existing treatments.

Because immunotherapy works differently from chemotherapy, side effects can also differ. Care teams closely monitor patients for immune reactions and provide supportive care to help manage symptoms and maintain quality of life throughout treatment.

Radiation Therapy

Radiation therapy uses high-energy beams to target and destroy cancer cells. It’s not typically used as a stand-alone treatment for mesothelioma, but radiation can play an important role when combined with other therapies.

At City of Hope Orange County, radiation therapy may be recommended:

After surgery to reduce the risk of the cancer coming back
To shrink tumors that can’t be surgically removed
To relieve symptoms such as chest pain and difficulty breathing

Advanced radiation techniques allow City of Hope doctors to target tumors while minimizing damage to healthy tissues. This is especially important in pleural mesothelioma, where tumors are located near the lungs and heart.

Palliative Care

Palliative care focuses on improving comfort and quality of life at any stage of mesothelioma. It’s not limited to end-of-life care and can be provided alongside standard treatments.

For patients with peritoneal mesothelioma, procedures such as paracentesis can help relieve abdominal fluid buildup (ascites). Palliative care can also involve medications to ease nausea or stomach discomfort, along with specialized nutritional support if appetite or digestion is affected.

Additional palliative care services may include:

Advanced pain management, including nerve blocks
Management of fatigue and treatment-related side effects
Oxygen therapy to ease shortness of breath
Physical therapy to maintain strength and mobility
Thoracentesis to drain excess fluid around the lungs (pleural effusion)

The goal of palliative care is to help patients feel as comfortable and supported as possible throughout their mesothelioma journey.

Download our Free Checklist of Questions to Ask Your Doctor to help ensure you understand your mesothelioma treatment options and know what to expect.

Mesothelioma Patient Care at City of Hope Orange County

Mesothelioma affects patients and loved ones physically and emotionally. City of Hope Orange County Lennar Foundation Cancer Center integrates supportive care into routine treatment to support families during treatment.

Support services for mesothelioma patients and families may include:

Behavioral health support
Diet and nutrition counseling
Pain management services
Respiratory therapy
Social workers specializing in cancer

The mesothelioma care team at City of Hope Orange County focuses on preserving patients’ quality of life while addressing their medical needs. Supportive care is available at every stage of treatment.

“The Sheri & Les Biller Patient and Family Resource Center at City of Hope Orange County Lennar Foundation Cancer Center provides a range of resources for patients and their loved ones as they navigate treatment and recovery.”
– City of Hope Orange County

Mesothelioma Clinical Trials and Research at City of Hope Orange County

City of Hope maintains a strong cancer and clinical research program. As an NCI-designated comprehensive cancer center, it participates in numerous clinical trials each year.

Mesothelioma clinical trials at City of Hope may study:

Advanced cell therapies
New chemotherapy combinations
Novel immunotherapy drugs
Precision medicines
Targeted therapies

Mesothelioma patients enrolling in clinical trials may gain access to emerging therapies that aren’t widely available. Each study follows strict NCI guidelines and is subject to federal oversight to protect patient safety.

Get matched with specialists at City of Hope Orange County to see if a clinical trial is right for you.

Get Mesothelioma Treatment at City of Hope Orange County

If you or a loved one has mesothelioma, City of Hope in Orange County, CA, offers specialized cancer care from doctors who treat this rare disease.

City of Hope Orange County mesothelioma patients have access to:

Clinical trials studying new mesothelioma therapies
A team approach that brings together different cancer specialists
Palliative care to help manage symptoms and side effects
Support services for patients and their families during treatment

We can connect you with experienced specialists at City of Hope Orange County and other top treatment centers near you. Call (866) 608-8933 or use our Free Doctor Match service to get started.