Mesothelioma Life Expectancy

Mesothelioma life expectancy is the estimated time a patient may live after a diagnosis. The average life expectancy with mesothelioma is 12-21 months, but no two patients will have the same experience. Learn how to increase your mesothelioma life expectancy with treatment and find hope in the stories of long-term survivors.

Medically reviewed by: Mark Levin, MD

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What Is the Average Life Expectancy With Mesothelioma?

Average Mesothelioma Life Expectancy With and Without Treatment

The average mesothelioma life expectancy with treatment is 12-21 months, according to a report in F1000Research.

However, many factors influence mesothelioma life expectancy — including overall health, cancer stage, and response to treatment — and each patient’s story is unique.

Your life expectancy is not set in stone. If you have mesothelioma cancer, treatments like surgery, chemotherapy, and immunotherapy can potentially help you live longer and spend more time with the people you love.

Key Facts on Malignant Mesothelioma Life Expectancy

  • The average mesothelioma life expectancy without treatment is 4-12 months, according to Cancer Therapy Advisor, and 12-21 months with treatment.
  • Mesothelioma survival rates measure the percentage of patients still alive a certain amount of time after their diagnosis, usually measured at 1, 3, and 5 years.
  • The 1-year survival rate for mesothelioma is 43.7%, according to the National Cancer Institute (NCI).

Survival statistics paint the big picture, but there are so many individual stories behind each diagnosis. Get our Free Survivors Guide to read about mesothelioma patients who are still thriving 15+ years later.

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Factors Impacting Mesothelioma Life Expectancy

How long someone will live after a mesothelioma diagnosis depends on multiple factors. The type of mesothelioma, stage of the cancer, cell type of the tumor, your overall health, and more can all influence your prognosis and life expectancy. Learn more about how each of these plays a role in mesothelioma survival.

1. Type of Mesothelioma

There are four types of mesothelioma that develop in different locations of the body.

  • Pleural mesothelioma starts in the lining of the lungs (pleura). On average, the pleural mesothelioma life expectancy is about 18 months.
  • Peritoneal mesothelioma develops in the abdominal lining (peritoneum). The average peritoneal mesothelioma life expectancy is 53 months with treatment.
  • Pericardial mesothelioma affects the lining surrounding the heart (pericardium). The average pericardial mesothelioma life expectancy is the shortest, just 2-6 months.
  • Testicular mesothelioma starts in the lining of the testes (tunica vaginalis). Patients diagnosed with this type have an average mesothelioma life expectancy of 7 months if they receive treatment.

“Life expectancy with mesothelioma depends on the stage of the disease. It depends on the cell type. I tell patients to stay in the here and now and go one day at a time.”

Amy Fair, RN, Mesothelioma Hope Patient Advocate, 20+ years of experience

2. Cancer Stage

The stage of cancer is a key part of determining mesothelioma life expectancy after diagnosis. Malignant pleural mesothelioma has four stages that indicate how far the cancer has spread. In many cases, the lower the stage, the better the life expectancy will be.

Peritoneal mesothelioma doesn’t have an official staging system, but some oncologists (cancer doctors) use other methods to determine the extent of the spread and a patient’s life expectancy.

StageTumor LocationAverage Life Expectancy
Stage 1The tumor is limited to one area of the pleura.21 months
Stage 2The tumor has spread to nearby lymph nodes.19 months
Stage 3The tumor has spread to more distant lymph nodes and possibly other organs.16 months
Stage 4The tumor has spread to distant organs.12 months

Source: Frontiers in Oncology

Survivor Surpasses His Mesothelioma Life Expectancy at Stage 4

While the average advanced mesothelioma life expectancy is just around one year, many patients have defied their doctors’ projections and gone on to become long-term survivors.

Take John Stahl, for instance — a retired construction worker who was diagnosed with stage 4 mesothelioma back in 2019 and is still going strong thanks to an accurate diagnosis and prompt treatment with chemotherapy. Although treatment side effects were challenging, John now says he’s “pretty well back to normal.”

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John Stahl Testimonial Video Thumbnail

Dee and John Stahl reached out to Simmons Hanly Conroy, a mesothelioma law firm, to pursue justice after John’s stage 4 mesothelioma diagnosis. Call (866) 608-8933 to see if the firm can help your family. View Transcript.

Duration: 4 min 40 sec

Dee Stahl:
The day started out fine. We got up and John, which is unusual for him, just came out of the bedroom
and just sat down and he said, “I just don’t feel good,” and I knew something was wrong because John
doesn’t complain. I said, “Well, I think we should probably go to the ER.”

They found out that there was over two liters of fluid on his left lung and they were amazed that he was
even able to breathe, period. They did a CAT scan then that’s when he just said, “You have stage four
mesothelioma, John.”

John Stahl:
I was kind of blank. I didn’t know what to think. I didn’t realize that my job had exposed me to this.

Dee Stahl:
We’re the Stahls. I’m Dee, and this is my husband, John.

John Stahl:
My name is John Stahl. I was first exposed to asbestos poisoning through the construction business,
through Sheetrock, through gaskets and piping all through my career, and I worked 43 years in construction business. If you don’t work, you don’t get paid. The first treatment was with chemotherapy and I went every two weeks. It didn’t take long, an hour or so, but it’d take me seven to 10 days to recover. That was hard for me because I’m a pretty active person.

Dee Stahl:
Asbestos is poison and it’s a prescription for death.

John Stahl:
Yeah.

Dee Stahl:
I don’t know …

John Stahl:
It’s not curable.

Dee Stahl:
Right.

John Stahl:
Well, at first it didn’t really sink in. The longer and longer I thought about it, it’s going to end my life
eventually, but I’m going to live it as well as I can.

Dee Stahl:
It made me mad and sad to think that these manufacturers could continue knowing that there was
asbestos that could hurt people, continued to make these products for how many years, years and years, and look what it’s done to the love of my life.

It’s heartbreaking. We filed a mesothelioma lawsuit because John deserves it. We found out about
Simmons Hanly Conroy when we received a letter introducing us to Todd, and within days, couple of
days, Todd called and we just clicked.

John Stahl:
Filing the lawsuit was easy because Todd made it easy. He explained what was going to happen. It was
pretty simple.

Dee Stahl:
It’s been fantastic. I can’t put into words because anytime Todd would call, it was, “How’s John doing?
How’s my buddy John doing and how are you doing?” He just made you comfortable. It was a great
experience.

John Stahl:
My kids are gonna be taken care of, Dee’s gonna be taken care of, so it’s a peace of mind knowing that I
don’t have to worry about them going down the road.

Dee Stahl:
I want people out there to realize that there is help and they can get assistance and get a settlement
from these manufacturers that continue to use this and know that it was dangerous for people.

John Stahl:
We filed a mesothelioma lawsuit to hold companies accountable. It’s important people understand that
there’s help and there’s people there willing to help them go through this process of making these
companies liable for what they’ve caused.

3. Cell Type

Tumors can be made up of three different mesothelioma cell types. Your cell type determines how aggressively the cancer may spread and how the cells may respond to treatment.

Epithelioid mesothelioma life expectancy is the longest of the three types, as it’s the least aggressive cell type and is the easiest to treat. However, there are treatment options that may help regardless of your cell type.

Cell TypeAverage Mesothelioma Life Expectancy
Epithelioid14 months
Sarcomatoid4 months
Biphasic10 months

4. Treatment Response

Another key factor in life expectancy is how well the body responds to treatment. Some people will see an immediate response to their initial treatment, while others will need to try different therapies until something works for them.

No two mesothelioma cases are exactly the same, but treatments like surgery, chemotherapy, and immunotherapy can help control the size and spread of the disease. If the body responds well, meaning the treatment shrinks or slows the cancer, life expectancy can increase significantly. A strong treatment response can mean living months or even years longer.

5. Age, Lifestyle, and Nutrition

Other factors that can impact someone’s mesothelioma life span include:

  • Age: Younger patients under the age of 50 have the highest survival rates based on data from the NCI.
  • Nutrition: Pleural mesothelioma survivor Arthur Putt tried several cancer treatments that came with a host of side effects but had limited results. By adding specific nutrients to his diet, he eased his side effects and strengthened his immune system. Arthur has now surpassed his life expectancy by over 7 years.
  • Overall health: Life expectancy is higher for non-smoking patients with no coexisting health conditions. These patients are usually eligible for mesothelioma surgery and tend to remain healthier for longer.
  • Sex: Women with mesothelioma live longer on average than men. According to the American Cancer Society (ACS), this might be because men have experienced longer and more frequent asbestos exposure in high-risk industries like shipbuilding and construction.

Use our Free Doctor Match to connect with a specialist who can help you improve your metastatic mesothelioma life expectancy.

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How to Improve Your Life Expectancy With Mesothelioma

Many mesothelioma survivors have far surpassed their initial life expectancy, which shows there is always hope.

Here are some ways you may be able to improve your life expectancy with mesothelioma:

  • Confirm your diagnosis is complete and correct. Getting a second opinion on your mesothelioma type, stage, and cell type ensures you’re receiving the most effective treatments.
  • Find a mesothelioma specialist. Work with an oncologist who has experience treating mesothelioma and knows which treatment options may work best for your specific diagnosis.
  • Manage your nutrition. Top mesothelioma cancer centers offer diet and nutrition support to help your body stay strong during the treatment process.
  • Pursue palliative care. Studies show palliative care — which focuses on symptom relief, pain management, and other quality-of-life improvements — can actually extend survival. The earlier you get this type of care, the better.

“If your doctor is not a professional and has not lived it and breathed it, get another oncologist. You need someone experienced — someone who’s going to fight for you and with you.”

Mary Jane Williams, 15-year mesothelioma survivor

Mesothelioma Life Expectancy With Treatment

The best way to increase your life expectancy after a mesothelioma diagnosis is with treatment from a specialist. Common treatments for mesothelioma include surgery, chemotherapy, immunotherapy, and radiation. New and emerging therapies are also showing promise in clinical trials.

Surgery

Patients who receive surgery have an average life expectancy of 19.8 months, according to a review of the National Cancer Database (NCDB).

Surgery allows mesothelioma doctors to physically remove as much of the cancer as possible.

Surgeries that can improve mesothelioma life expectancy include:

  • Pleurectomy/decortication (P/D) for pleural mesothelioma. Patients have an average life expectancy of 34 months.
  • Extrapleural pneumonectomy (EPP) for pleural mesothelioma. Recent studies show that patients who get an EPP followed by chemotherapy and radiation live about 15-20 months, with some surviving up to 3 years if the cancer is caught early.
  • Cytoreduction with HIPEC for peritoneal mesothelioma. Patients who undergo this procedure live 53 months on average.

Patients may receive chemotherapy, radiation therapy, or a combination of both treatments alongside surgery.

Chemotherapy

According to an OncLive report, mesothelioma patients who receive chemotherapy have an average life expectancy of 14.1 months. Those who qualify for surgery before or after chemotherapy typically have a longer life expectancy.

Mesothelioma chemotherapy involves administering powerful cancer-fighting medications through an IV in multiple cycles with periods of recovery between each session.

Jill Litton was diagnosed with peritoneal mesothelioma in 2009, shortly after she celebrated her 50th birthday. She was given fewer than 2 years to live. However, she was determined to fight for more time with her family.

“Just because you have cancer and your doctor says you have a year to live doesn’t mean you must suddenly agree to those terms.”

Jill Litton, 16+ year mesothelioma survivor

Jill received the chemotherapy medications pemetrexed and cisplatin and later underwent cytoreductive surgery with heated chemotherapy. This treatment combination — along with her strong faith and optimism — helped her beat her prognosis and make more memories with her children and grandchildren.

You can read more about Jill’s journey and get tips for improving your life expectancy in our Free Mesothelioma Survivors Guide.

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Immunotherapy

Immunotherapy works by training the body’s immune system to better recognize and attack tumor cells, slowing down cancer growth. Although it’s a relatively newer treatment option for mesothelioma, it’s gaining in popularity, and many patients have seen promising results.

There are two immunotherapy drug regimens for mesothelioma as of 2025:

  • Opdivo and Yervoy®: Patients treated with these two immunotherapy drugs have an average mesothelioma life span of 18.1 months, according to results from the CheckMate 743 trial.
  • Keytruda®: The KEYNOTE-483 trial found that mesothelioma patients treated with Keytruda and chemotherapy lived 19.8 months, compared to 8.9 months with chemotherapy alone.

Download the updated 3rd edition of our Free Immunotherapy Guide to learn more about the average mesothelioma life expectancy with immunotherapy, how this promising treatment works, and tips for managing side effects.

Radiation Therapy

Radiation therapy damages the DNA of cancer cells, causing them to die or stop dividing. According to the NCDB, the average mesothelioma life expectancy with radiation therapy is 12.2 months.

Radiation is a key part of multimodal treatment plans for mesothelioma and can be combined with surgery and chemotherapy to make them more effective and potentially extend life expectancy.

Mesothelioma Life Expectancy Without Treatment

When mesothelioma is left untreated, life expectancy is unfortunately limited.

  • Pleural mesothelioma has an average life expectancy of about 4 to 12 months without treatment.
  • Peritoneal mesothelioma has a slightly longer survival time of 6 to 12 months without medical care.

These numbers can feel overwhelming, but they’re just averages. Factors like age, overall health, and how quickly the cancer is growing can all play a role in how long you or your loved one may live after a diagnosis.

Even if you decide not to get standard treatment, palliative care can make your symptoms more manageable and improve your quality of life.

Get Help Improving Your Life Expectancy With Mesothelioma Cancer

If you or a family member is facing mesothelioma, remember that there’s always hope. Even patients who have been given just months to live have become long-term survivors in some cases.

It’s possible to live a full life with this cancer, and Mesothelioma Hope is here to guide you toward a path of healing.

Our nurses and Patient Advocates can help you:

  • Connect with doctors who can recommend life-extending treatment
  • Find the latest clinical trials
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Call (866) 608-8933 to speak with us right now or get started with our Free Doctor Match.

Life Expectancy With Mesothelioma FAQs

How long can you live with mesothelioma?

Most people with mesothelioma live between 12 and 21 months with treatment, but this is just an estimate. 

Factors like the type of mesothelioma, how early it’s found, and your overall health can play a role in life expectancy.

The good news is that treatments are getting more effective, and doctors are finding new ways to help people live longer with this disease.

Has anyone beat mesothelioma?

Yes, there have been cases of patients achieving remission from mesothelioma. Remission occurs when doctors cannot find evidence of cancer in a patient’s body.

One example is mesothelioma survivor Mary Jane Williams, who was cancer-free for 14 years when she passed away from Alzheimer’s disease in 2018.

What is the life expectancy of someone with stage 4 mesothelioma?

The life expectancy of someone with stage 4 mesothelioma can vary, but the average for stage 4 is 12 months. Some people live much longer, especially with early detection and newer treatments like immunotherapy.

There are survivors who are still thriving several years beyond their original mesothelioma prognosis, including John Stahl, who was diagnosed with stage 4 mesothelioma in 2019 and is living life to the fullest today.

What is the average mesothelioma life expectancy without treatment?

The average mesothelioma life expectancy without treatment ranges from 4 months to 1 year, depending on the type of cancer and other factors.

  • Pleural mesothelioma: 4-12 months without treatment
  • Peritoneal mesothelioma: 6-12 months without treatment

These figures highlight how important it is to start treatment as soon as you or a loved one has been diagnosed with mesothelioma.

If you’re concerned about side effects from treatment, reach out to our team to learn about palliative care options that can help manage side effects and improve your quality of life.

What is the life expectancy with mesothelioma by stage?

The stage of mesothelioma indicates how far the cancer has spread from its point of origin. Pleural mesothelioma is the only type of this cancer that has a formal staging system. Below is the average life expectancy after a mesothelioma diagnosis for each stage based on data from Frontiers in Oncology.

  • Stage 1 mesothelioma life expectancy: 21 months
  • Stage 2 mesothelioma life expectancy: 19 months
  • Stage 3 mesothelioma life expectancy: 16 months
  • Stage 4 mesothelioma life expectancy: 12 months
Dr. Mark LevinReviewed by:Mark Levin, MD

Certified Oncologist and Hematologist

  • Fact-Checked
  • Editor

Mark Levin, MD, has over 30 years of experience in academic and community hematology and oncology. In addition to serving as Chief or Director at four different teaching institutions throughout his life, he is still a practicing clinician, has taught and designed formal education programs, and has authored numerous publications in various fields related to hematology and oncology.

Dr. Mark Levin is an independently paid medical reviewer.

  • Board Certified Oncologist
  • 30+ Years Experience
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Jenna Tozzi, RN, is the Chief Patient Care Advisor for Mesothelioma Hope. With more than 15 years of experience as an adult and pediatric oncology nurse navigator, Jenna provides exceptional guidance and support to cancer patients and their loved ones. Jenna has been featured in Oncology Nursing News and is a member of the Academy of Oncology Nurse & Patient Navigators & the American Nurses Association.

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References
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